Will Your Medications
Actually Work for You?
Roughly 7% of people have genetic variants that make standard medication doses ineffective or dangerous. Pharmacogenomics testing — built into Atlagene Premium — checks 200+ drug-gene interactions from the same DNA file you already have.
The Basics
What Is Pharmacogenomics?
Pharmacogenomics (PGx) is the study of how your genes affect the way you respond to medications. Two people taking the same standard dose of the same drug can metabolize it at very different rates — one might need 10x more to feel any effect, while another could experience severe side effects at the normal dose.
Most of this variation comes from genes that code for drug-metabolizing enzymes (the CYP450 family — CYP2D6, CYP2C19, CYP3A5), drug transporters (SLCO1B1, ABCG2), and immune-system markers (HLA-B). The FDA now includes PGx information on over 280 medication labels.
CPIC (the Clinical Pharmacogenetics Implementation Consortium) publishes evidence-graded guidelines for over 100 drug-gene pairs. Atlagene's pharmacogenomics report follows CPIC Level A/B recommendations — the highest evidence tier.
What We Check
200+ Drug Interactions, 4 Categories
FDA Boxed-Warning Variants
Variants where FDA labels mandate genetic testing or carry boxed warnings.
Examples: Carbamazepine (HLA-B*15:02), Abacavir (HLA-B*57:01), Codeine (CYP2D6), 5-FU/Capecitabine (DPYD), Thiopurines (TPMT/NUDT15)
Cardiovascular
Anticoagulants, antiplatelets, and lipid-lowering therapy.
Examples: Warfarin (CYP2C9, VKORC1), Clopidogrel (CYP2C19), Statins (SLCO1B1, ABCG2)
Mental Health
SSRIs, antipsychotics, and pain medications.
Examples: SSRIs (CYP2D6, CYP2C19), Tricyclics (CYP2D6), Opioids (CYP2D6, OPRM1)
Immunosuppressants & Chemo
Cancer therapy and transplant medications.
Examples: Tacrolimus (CYP3A5), Azathioprine (TPMT), Irinotecan (UGT1A1)
Real-World Stakes
Three Variants That Save Lives
HLA-B*15:02 + Carbamazepine
Carriers of HLA-B*15:02 have up to 1,000x higher risk of life-threatening Stevens-Johnson Syndrome from carbamazepine. Most common in people of Han Chinese, Thai, and Filipino ancestry. The FDA requires testing before prescribing.
DPYD + 5-FU / Capecitabine
DPYD-deficient patients can experience fatal toxicity from standard 5-fluorouracil chemotherapy doses. Roughly 3-5% of the population carries reduced-function DPYD variants; testing is now standard of care in oncology.
CYP2D6 + Codeine in Children
Ultra-rapid CYP2D6 metabolizers convert codeine to morphine far faster than normal — children with this variant have died from standard codeine doses post-tonsillectomy. The FDA boxed-warned codeine in pediatric tonsillectomy patients in 2013.
Your Atlagene PGx Report
What You'll Actually See
- Per-drug guidance: standard dose, reduced dose needed, alternative medication suggested
- Phenotype calls (poor / intermediate / normal / rapid / ultra-rapid metabolizer) for each enzyme
- CPIC-graded recommendations with citations
- FDA boxed-warning flags surfaced prominently
- Population-equity coverage: African-ancestry CYP2C9 *5/*6/*8/*11 + CYP2D6*17 + CYP2B6*18 alleles included
- Shareable PDF report you can hand to your prescriber
A note on scope
Atlagene's pharmacogenomics output is informational only. It does not replace your prescriber's judgment. Never start, stop, or adjust medications based on a genetic report alone. Bring the report to your physician or pharmacist; most are familiar with CPIC guidelines.
Already Have a DNA File?
Pharmacogenomics is included in every Premium plan. Upload your existing 23andMe, Ancestry, or VCF file — no new test required.
Start Premium — $14.99/moCancel anytime · 7-day free trial on annual plans